anti-TNF therapy

https://clinicaltrials.gov/ct2/show/NCT02469753?type=Intr&cond=ankylosing+spondylitis&phase=0124&lupd_s=01%2F17%2F2020&lupd_d=14&sort=nwst

STUDY TITLE:
Interest of Continuous Non-Steroidal Anti-Inflammatory Drug Treatment in Ankylosing Spondylitis Patients Treated by Anti-TNF Therapy in the Prevention of Radiographic Outcomes

DESCRIPTION:
Condition: Ankylosing Spondylitis
Interventions: Drug: NSAIDs; Drug: anti-TNF
Sponsor: University Hospital, Bordeaux
Recruiting

CLINICALTRIALS.GOV IDENTIFIER:
NCT02469753

FIRST POSTED:
Thu, 11 Jun 2015 12:00:00 EDT

LAST UPDATE POSTED:
01/31/20 07:33AM

STUDY LINK / URL:
https://clinicaltrials.gov/ct2/show/NCT02469753?type=Intr&cond=ankylosing+spondylitis&phase=0124&lupd_s=01%2F17%2F2020&lupd_d=14&sort=nwst

https://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.13734

https://www.ncbi.nlm.nih.gov/pubmed/31647182?dopt=Abstract

TITLE:
Potential utility of anti-TNF drugs in synovial chondromatosis associated with ankylosing spondylitis.

DESCRIPTION:
Potential utility of anti-TNF drugs in synovial chondromatosis associated with ankylosing spondylitis.

Int J Rheum Dis. 2019 Oct 24;:

Authors: Yu S, Wu M, Zhou G, Ishikawa T, Liang J, Nallapothula D, Singh RR, Wang Q, Wang M

Abstract

We describe a previously unreported association of ankylosing spondylitis with synovial chondromatosis, and briefly review previously reported cases and treatment of synovial chondromatosis in patients with other immune-mediated inflammatory arthritides. A 20-year-old man with ankylosing spondylitis whose axial disease was in remission with nonsteroidal anti-inflammatory drugs and oral disease-modifying anti-rheumatic drugs developed recurrent right knee pain and swelling. Magnetic resonance imaging of his right knee revealed calcified loose bodies, suggestive of synovial chondromatosis. While waiting for the surgical intervention and other invasive therapy previously reported in patients with synovial chondromatosis, a trial of etanercept eliminated the pain and swelling of the knee; however, the loose bodies have persisted during the 2-year follow-up. Thus, synovial chondromatosis should be considered in the differential diagnoses of a refractory monoarticular pain and swelling in patients with otherwise controlled inflammatory arthritis. Our report advocates a trial of anti-tumor necrosis factor drugs, which might delay the need for invasive therapy in patients with synovial chondromatosis.

PMID: 31647182 [PubMed – as supplied by publisher]

PMID:
PubMed:31647182

DATE FOUND:
10/25/19 06:59PM

LINK / URL:
https://www.ncbi.nlm.nih.gov/pubmed/31647182?dopt=Abstract