This page keeps track of new/upcoming treatment options for ankylosing spondylitis (AS). What’s in development? What’s promising? What’s available soon? Find out below… Current topics include BCD-085 (netakimab), KIN-1901 (gimsilumab), TNF inhibitors, IL-17 inhibitors, DKK-1, nanocurcumin, upadacitinib, iguratimod, gut microbiome, emodin, miR-451, and more.
Last updated: 1 year ago
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News
- New Treatment Approved for Ankylosing Spondylitis: FDA OKs First JAK Inhibitor, Tofacitinib Dec 17, 2021
- AbbVie Submits Regulatory Application to FDA for RINVOQ™ (upadacitinib) for the Treatment of Adults with Active Ankylosing Spondylitis Sep 12, 2020
- Rinvoq (upadacitinib) submitted for approval in ankylosing spondylitis Aug 25, 2020
- Treatment With TNF Inhibitors Slows Radiographic Progression in Ankylosing Spondylitis Aug 4, 2020
- Ankylosing spondylitis (AS): Becoming a mother despite having a rheumatic disease Aug 4, 2020
- Newly identified cell type may help predict, treat autoimmune conditions with flare-ups, including ankylosing spondylitis Jul 17, 2020
- IL-17 inhibitors effective for ankylosing spondylitis, but boost infection risk Jun 25, 2020
- IL-17A Blockers Succeed in Spine Disease — Secukinumab and ixekizumab superior to placebo for ankylosing spondylitis May 13, 2020
- High Levels of Protein Found in Bones and Gut May Link Ankylosing Spondylitis and IBD Apr 27, 2020
- IL-17A/F Inhibitor a Winner in Spine Disease — Targeting both cytokines had rapid, sustained benefits in ankylosing spondylitis Apr 9, 2020
- Preliminary findings suggest no need for preventive DMARD withdrawal during COVID-19 pandemic Apr 3, 2020
- Kinevant Sciences Begins Phase 1 Trial of Immunoglobulin Monoclonal Antibody (mAb) KIN-1901 (Gimsilumab) for Ankylosing Spondylitis Mar 20, 2020
- FDA Approves Label Update for Secukinumab in Ankylosing Spondylitis Feb 29, 2020
- Study Questions BASDAI for Prescribing TNF Inhibitors in Ankylosing Spondylitis Feb 7, 2020
- Overexpression of LncRNA MEG3 Inhibits Inflammation in Ankylosing Spondylitis Jan 29, 2020
- The Role of the Gut Microbiome in Ankylosing Spondylitis (Update) Jan 23, 2020
- Altered Gut Microbiome Contributes to Inflammation in Ankylosing Spondylitis, Study Suggests Jan 23, 2020
- CIMZIA (certolizumab pegol) Now Approved in Canada for the Treatment of Non-Radiographic Axial Spondyloarthritis Jan 15, 2020
- Metagenomic Sequencing Reconfirms Key Role of Gut Microbiome in Ankylosing Spondylitis (AS) Pathogenesis Jan 7, 2020
- The Spondylitis Association of America Releases Its Axial Spondyloarthritis Treatment Recommendations for Patients and Families Dec 5, 2019
- AbbVie presents new data for ankylosing spondylitis treatment in US Nov 15, 2019
- Novartis receives approval for Cosentyx® label update in Europe to include dosing flexibility in ankylosing spondylitis Oct 24, 2019
- Anti-TNF Therapy Slows Down AS Progression and Bone Loss, Study Says Oct 10, 2019
- Novartis Eyes New Cosentyx Approval After Positive Axial Spondyloarthritis Trial Oct 3, 2019
- Filgotinib Could Be Effective for Treating Ankylosing Spondylitis Sep 28, 2019
- Adalimumab, IBI303 biosimilar demonstrate comparable safety, efficacy in AS Sep 19, 2019
- Novartis Cosentyx® positive 16-week PREVENT results advance potential new indication for patients with axial spondyloarthritis Sep 17, 2019
- Novartis Announces New Data on Spondylitis Drug Cosentyx Sep 17, 2019
- Lilly’s Taltz wins third approval, this time in patients with active ankylosing spondylitis Aug 26, 2019
- Ixekizumab Gains FDA Approval for Treatment of Active Ankylosing Spondylitis Aug 26, 2019
- Prevention in the 2020s: what it means for axial SpA (AS) Jul 22, 2019
- Plant Compound Emodin Could be Used as Treatment for AS, Study Says Feb 18, 2019
- New Research Highlights the Role of Biosimilar Etanercept in Treating Ankylosing Spondylitis Feb 13, 2019
- Lilly Announces Positive Results for Two Phase 3 Studies of Taltz (ixekizumab) in Ankylosing Spondylitis Oct 22, 2018
Research
- Efficacy and safety of Duhuo Jisheng decoction combined with Western medicine in the treatment of ankylosing spondylitis: A systematic review and meta-analysis Feb 18, 2023
- Dual-specificity phosphatases 22-deficient T cells contribute to the pathogenesis of ankylosing spondylitis Feb 10, 2023
- Pain and Fatigue in Patients With Ankylosing Spondylitis Treated With Tumor Necrosis Factor Inhibitors: Multinational Real-World Findings Aug 20, 2020
- Is fibromyalgia frequency increasing in axial spondyloarthritis? Association with fibromyalgia and biological therapies Aug 7, 2020
- A prospective study of novel disease activity indices for ankylosing spondylitis Aug 5, 2020
- Anemia in patients with ankylosing spondylitis, association with the activity of the inflammatory process and the severity of the disease Aug 1, 2020
- The effectiveness of Du moxibustion for ankylosing spondylitis: A protocol for systematic review and meta-analysis of randomized clinical trials Jul 31, 2020
- GM-CSF Primes Proinflammatory Monocyte Responses in Ankylosing Spondylitis Jul 16, 2020
- The changing profile of ankylosing spondylitis in the biologic era Jul 9, 2020
- MicroRNA‑204‑5p inhibits the osteogenic differentiation of ankylosing spondylitis fibroblasts by regulating the Notch2 signaling pathway Jul 6, 2020
- TNF-α inhibitor therapy can improve the immune imbalance of CD4+ T cells and negative regulatory cells but not CD8+ T cells in ankylosing spondylitis Jun 19, 2020
- The Efficacy and Safety of Simple-Needling Therapy for Treating Ankylosing Spondylitis Jun 13, 2020
- IL6 May Represent a Useful Biomarker for Diagnosing Ankylosing Spondylitis Jun 6, 2020
- Molecular mechanisms and clinical studies of iguratimod for the treatment of ankylosing spondylitis Jun 6, 2020
- Down-regulated miR-495 can target programmed cell death 10 in ankylosing spondylitis: a potential molecular marker for the diagnosis and treatment of AS May 25, 2020
- Dihydrotestosterone (DHT) inhibition might increase the progression of spinal ankylosis despite the higher levels of DHT observed in many AS patients May 24, 2020
- Clinical efficacy of golimumab in the treatment of ankylosing spondylitis May 23, 2020
- Effect of TNF-inhibitor therapy on spinal structural progression in ankylosing spondylitis patients: A systematic review and meta-analysis. May 17, 2020
- Efficacy and Safety of Sinomenine Preparation for Ankylosing Spondylitis May 15, 2020
- Efficacy and safety of IL-17 inhibitors for the treatment of ankylosing spondylitis: a systematic review and meta-analysis May 12, 2020
- Therapeutic Potential of Ixekizumab in the Treatment of Ankylosing Spondylitis: A Review on the Emerging Clinical Data Apr 16, 2020
- Dual neutralisation of interleukin-17A and interleukin-17F with bimekizumab in patients with active ankylosing spondylitis: results from a 48-week phase 2b, randomised, double-blind, placebo-controlled, dose-ranging study Apr 6, 2020
- Therapeutic, diagnostic significance, and prognostic value of dickkopf-related protein-1 (DKK-1) and tumor necrosis factor-α (TNF-α) in ankylosing spondylitis Apr 6, 2020
- Janus Kinase Inhibitors: State of the Art in Clinical Use and Future Perspectives Mar 26, 2020
- Dynamic changes in gut microbiota under the influence of smoking and TNF-α-blocker in patients with ankylosing spondylitis Mar 26, 2020
- Lipocalin 2 links inflammation and ankylosis in the clinical overlap of inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) Mar 18, 2020
- TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis Mar 9, 2020
- TNF Receptor:Fc Fusion Protein (rhTNFR:Fc) suppresses inflammation and bone destruction of ankylosing spondylitis by reducing the RANKL/OPG ratio through inhibition of the CXCL16/CXCR6 pathway Mar 1, 2020
- A systematic review and network meta-analysis of current and investigational treatments for active ankylosing spondylitis Feb 27, 2020
- Is Any Correlation Present Between the Severity of Syndesmophytes and Spinopelvic and Clinical Parameters in Advanced Ankylosing Spondylitis? Feb 24, 2020
- Huangqin Qingre Chubi Capsules (HQC) improves clinical symptoms and oxidative stress of ankylosing spondylitis patients via activating PPARγ mediated AMPK/FOXO3a pathway Feb 2, 2020
- S100A4 is elevated in axial spondyloarthritis: a potential link to disease severity Jan 31, 2020
- miR-21 may Act as a Potential Mediator Between Inflammation and Abnormal Bone Formation in Ankylosing Spondylitis Jan 21, 2020
- Improvement of conjunctival cytological grade and tear production in Ankylosing Spondylitis patients under TNF inhibitors: a long-term follow-up Jan 15, 2020
- IL-23 and IL-17 cytokine levels might be an important factor in ankylosing spondylitis (AS) patients who are unresponsive to biologics Dec 16, 2019
- Shotgun metagenomics reveals an enrichment of potentially cross-reactive bacterial epitopes in ankylosing spondylitis patients, as well as the effects of TNFi therapy upon microbiome composition Dec 16, 2019
- Notoginsenoside R1 suppresses miR-301a via NF-κB pathway in lipopolysaccharide-treated ATDC5 cells Dec 11, 2019
- Metagenomic profiling of the pro-inflammatory gut microbiota in ankylosing spondylitis Dec 2, 2019
- Increased BMPR1A Expression Enhances the Adipogenic Differentiation of Mesenchymal Stem Cells in Patients with Ankylosing Spondylitis Nov 18, 2019
- Efficacy and safety of upadacitinib in patients with active ankylosing spondylitis (SELECT-AXIS 1 phase 2/3 trial results) Nov 12, 2019
- HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis Nov 4, 2019
- Efficacy and safety of ixekizumab through 52 weeks in two phase 3, randomised, controlled clinical trials in patients with active radiographic axial spondyloarthritis Nov 4, 2019
- Advances in nanomedicine for the treatment of ankylosing spondylitis Oct 29, 2019
- Potential utility of anti-TNF drugs in synovial chondromatosis associated with ankylosing spondylitis Oct 24, 2019
- Advances in nanomedicine for the treatment of ankylosing spondylitis Oct 19, 2019
- Anti-TNF-α therapy alters the gut microbiota in proteoglycan-induced ankylosing spondylitis in mice Sep 26, 2019
- Comparison of disease activity in patients with ankylosing spondylitis under TNFi or NSAID treatment, is there any difference? Sep 24, 2019
- Efficacy of wIRA in the treatment of sacroiliitis in male patients with ankylosing spondylitis and its effect on serum VEGF levels Sep 18, 2019
- miR-29a promotes osteoblast proliferation by downregulating DKK-1 expression and activating Wnt/β-catenin signaling pathway Sep 16, 2019
- Effects of 1-year anti-TNF-α therapies on bone mineral density and bone biomarkers in rheumatoid arthritis and ankylosing spondylitis Sep 14, 2019
- Long-term efficacy and safety of secukinumab 150 mg in ankylosing spondylitis: 5-year results from the phase III MEASURE 1 extension study Sep 3, 2019
- Expression and function of Toll‑like receptors in peripheral blood mononuclear cells in patients with ankylosing spondylitis Sep 2, 2019
- Baseline Interleukin-6 and Erythrocyte Sedimentation Rate Can Predict Clinical Response of TNF Inhibitor Treatment in Patients with Ankylosing Spondylitis Sep 1, 2019
- Comparative persistence on methotrexate and TNF inhibitors in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis Sep 1, 2019
- Risk of immune-mediated inflammatory diseases in newly diagnosed ankylosing spondylitis patients Aug 29, 2019
- 2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis Aug 22, 2019
- Water therapy can benefit patients with ankylosing spondylitis by reducing disease activity and alleviating pain Jul 29, 2019
- Mud-bath treatment of seronegative spondyloarthritis Jul 24, 2019
- MiR-451 suppresses inflammatory responses in ankylosing spondylitis by targeting macrophage migration inhibitory factor Jul 8, 2019
- Prostaglandin receptor EP4 expression by Th17 cells is associated with high disease activity in ankylosing spondylitis Jun 28, 2019
- IgG Galactosylation status combined with MYOM2-rs2294066 precisely predicts anti-TNF response in ankylosing spondylitis Jun 13, 2019
- ILC3 in Axial Spondyloarthritis: the Gut Angle Jun 13, 2019
- Bimekizumab: The First Dual Inhibitor of Interleukin (IL)-17A and IL-17F for the Treatment of Psoriatic Disease and Ankylosing Spondylitis Jun 6, 2019
- The effects of nanocurcumin on Treg cell responses and treatment of ankylosing spondylitis patients May 9, 2019
- LILR and KIR receptors recognize HLA-B27 and may influence immune response in ankylosing spondylitis (AS) development Mar 20, 2019
- Rifaximin Alters Intestinal Microbiota and Prevents Progression of Ankylosing Spondylitis in Mice Mar 4, 2019
- Nanocurcumin: A novel strategy in treating ankylosing spondylitis by modulating Th17 cells frequency and function Feb 25, 2019
- Emodin induces apoptosis and autophagy of fibroblasts obtained from patient with ankylosing spondylitis Feb 11, 2019
- The safety and efficacy of Guluronic acid (G2013) in ankylosing spondylitis: could be appropriate for management of AS Feb 10, 2019
- HLA alleles associated with risk of ankylosing spondylitis and rheumatoid arthritis influence the gut microbiome Jan 11, 2019
Clinical Trials
- A Study of Comparing Overall Improvement of Patients With Spondyloarthritis Treated With Jitongning Tablets and Placebo Aug 21, 2023
- Safety and Tolerance of Umbilical Cord Mesenchymal Stem Cells (UC-MSC) in Patients With Ankylosing Spondylitis Jul 27, 2023
- Efficacy and Safety Study of Jaktinib in Subjects With Active Ankylosing Spondylitis(AS) May 16, 2023
- Efficacy and Safety Clinical Study of VC005 Tablets in Subjects With Active Ankylosing Spondylitis. Apr 18, 2023
- Jacketinib Hydrochloride Tablets In The Treatment of Active Ankylosing Spondylitis Aug 11, 2020
- Efficacy and Safety Study of SUNPG1622 [Terminated] Jul 28, 2020
- Study to Evaluate the Efficacy and Safety of Filgotinib JAK-1 Inhibitor (GS-6034) in Participants With Active Ankylosing Spondylitis Who Are Naive to Biologic Disease-Modifying Antirheumatic Drug Therapy Jul 23, 2020
- Study to Evaluate the Efficacy and Safety of Filgotinib in Participants With Active Ankylosing Spondylitis Who Have an Inadequate Response to Biologic Disease-Modifying Antirheumatic Drug Therapy Jul 23, 2020
- Efficacy and Safety of BCD-085 in Patients With Active Ankylosing Spondylitis [Completed] Jul 22, 2020
- International Multicenter Comparative Randomized Placebo-controlled Clinical Study of Efficacy and Safety of BCD-085 in Patients With Ankylosing Spondylitis Jul 22, 2020
- A Study to Evaluate the Efficacy and Safety of SHR0302 in Patients With Ankylosing Spondylitis Jul 22, 2020
- Bawei Shenqi Pill in the Treatment of Ankylosing Spondylitis Jul 21, 2020
- A Study to Evaluate the Efficacy and Safety of Bimekizumab in Subjects With Active Ankylosing Spondylitis [Completed] Jul 17, 2020
- A Study to Evaluate the Long-term Safety, Tolerability and Efficacy of Bimekizumab in Subjects With Active Axial Spondyloarthritis Including Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis Jun 18, 2020
- Safety and Efficacy Study of Prefilled Liquid Etanercept(Yisaipu) for Active Ankylosing Spondylitis [Completed] Apr 14, 2020
- Phase 1 Study With KIN-1901 in Healthy Subjects and Subjects With Ankylosing Spondylitis [Completed] Apr 13, 2020
- A Study Evaluating the Safety and Efficacy of Upadacitinib in Subjects With Active Ankylosing Spondylitis ( SELECT Axis 1 ) Apr 8, 2020
- Effect of Secukinumab on Radiographic Progression in Ankylosing Spondylitis as Compared to GP2017 (Adalimumab Biosimilar) Mar 12, 2020
- Comparison of PK and Tolerability of MSB11022 Administered by AI or PFS Feb 6, 2020
- Interest of Continuous Non-Steroidal Anti-Inflammatory Drug Treatment in Ankylosing Spondylitis Patients Treated by Anti-TNF Therapy Jan 31, 2020
- Efficacy and Safety of Tofacitinib in Subjects With Active Ankylosing Spondylitis (AS) Jan 14, 2020
- A Study to Test the Efficacy and Safety of Bimekizumab and Certolizumab Pegol in Patients With Active Ankylosing Spondylitis Jan 6, 2020
- Ascending Single/Multiple-Dose Phase 1 Study With KIN-1901 (Gimsilumab) in Healthy Subjects and Subjects With Ankylosing Spondylitis Dec 20, 2019
- Study to Demonstrate the Efficacy, Safety and Tolerability of an Intravenous Regimen of Secukinumab Compared to Placebo in Subjects With Active axSpA Nov 7, 2019
- Study to Evaluate the Efficacy and Safety of BAT1406 Injection and Humira in the Treatment of Ankylosing Spondylitis [Completed] Oct 22, 2019
- Study of Efficacy and Safety of Secukinumab in Patients With Ankylosing Spondylitis [Completed] Oct 10, 2019
- A Study to Evaluate the Efficacy and Safety of Bimekizumab in Subjects With Active Ankylosing Spondylitis Oct 1, 2019
- Treat-to-target Strategy in Ankylosing Spondylitis Using Etanercept and Conventional Synthetic DMARDs Sep 26, 2019
- Study to Test the Efficacy and Safety of Bimekizumab and Certolizumab Pegol in Patients With Active Ankylosing Spondylitis Sep 17, 2019
- Effect of Secukinumab on Radiographic Progression in Ankylosing Spondylitis as Compared to GP2017 (Adalimumab Biosimilar) (SURPASS) Sep 2, 2019
- Study of Efficacy and Safety of BCD-085 in Patients With Ankylosing Spondylitis May 24, 2019
- A Study Evaluating the Safety and Efficacy of Upadacitinib in Subjects With Active Ankylosing Spondylitis May 22, 2019
- The Effects of Nanocurcumin on Treg Cells and Th17 Cells Responses in Ankylosing Spondylitis Patients [Completed] May 17, 2019
